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. 2020 May 17;94(5):1739–1751. doi: 10.1007/s00204-020-02779-2

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — Biological functions and pathways predicted to be activated or inactivated by PA according to Ingenuity Pathway Analysis (IPA). A set of 284 significantly (q < 0.05) dysregulated rat liver transcripts was analyzed with IPA. Canonical pathways (a), diseases and biofunctions (b) and hepatotoxic functions (c) are displayed. The heatmaps show activation z-scores for the respective canonical pathways. For diseases and biofunctions, the 30 diseases and functions with the highest positive or the lowest negative activation z-scores are shown. Hepatotoxic functions were identified by IPA analysis for activation/inactivation of diseases and functions, filtered for hepatotoxicity. A complete list of affected functions is presented in the supplemental material