Table 3.
Overview of different pharmacokinetics values for risperidone and 9-hydroxyrisperidone between different age groups: young adults (18–35 years), young-olds (65–74 years), medium-olds (75–84 years), and oldest-old (85–100 years). EM: extensive metabolizer; IM: intermediate metabolizer; PM: poor metabolizer; UM: ultra-rapid metabolizer
| Risperidone | 9-hydroxyrisperidone | ||||||
|---|---|---|---|---|---|---|---|
| Ratio young-old/young adults | Ratio medium-old/young adults | Ratio oldest-old/young adults | Ratio young-old/young adults | Ratio medium-old/young adults | Ratio oldest-old/young adults | ||
| AUC (μg*h/l) | EM | 1.20 | 1.38 | 1.49 | 1.09 | 1.22 | 1.39 |
| IM | 1.20 | 1.37 | 1.51 | 1.09 | 1.21 | 1.38 | |
| PM | 1.21 | 1.36 | 1.52 | 1.15 | 1.18 | 1.34 | |
| UM | 1.19 | 1.38 | 1.47 | 1.09 | 1.21 | 1.39 | |
| Cmax (μg/L) | EM | 1.08 | 1.19 | 1.29 | 1.07 | 1.18 | 1.36 |
| IM | 1.12 | 1.24 | 1.37 | 1.08 | 1.19 | 1.37 | |
| PM | 1.17 | 1.29 | 1.44 | 1.07 | 1.18 | 1.35 | |
| UM | 1.06 | 1.16 | 1.24 | 1.07 | 1.18 | 1.35 | |
| tmax (h) | EM | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 |
| IM | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | |
| PM | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | |
| UM | 1.09 | 1.09 | 1.09 | 1.00 | 1.00 | 1.00 | |
| t1/2 (h) | EM | 1,09 | 1,15 | 1,14 | 1,04 | 1,04 | 1,03 |
| IM | 1,07 | 1,11 | 1,11 | 1,04 | 1,02 | 1,00 | |
| PM | 1,08 | 1,10 | 1,10 | 0,98 | 0,85 | 0,74 | |
| UM | 1,10 | 1,17 | 1,16 | 1,04 | 1,04 | 1,04 | |