Table 17.
Relative organ weights in male and female Wistar Han RCC rats in the combined chronic toxicity/carcinogenicity feeding trial with GM maize NK603 at an inclusion rate of 11 and 33% in the diet (at t = 12 months)
Organ | Relative organ weights (organ weight/body weight × 100) | ||||
---|---|---|---|---|---|
33% Control | 11% NK603 | 33% NK603 | 11% NK603 + Roundup | 33% NK603 + Roundup | |
Male rats | |||||
Adrenal glands | 0.009 ± 0.001 | 0.009 ± 0.001 | 0.009 ± 0.001 | 0.008 ± 0.001 | 0.009 ± 0.001 |
Brain | 0.38 ± 0.03 | 0.40 ± 0.05 | 0.39 ± 0.04 | 0.37 ± 0.04 | 0.39 ± 0.04 |
Epididymides | 0.22 ± 0.02 | 0.24 ± 0.03a | 0.22 ± 0.03 | 0.21 ± 0.03 | 0.23 ± 0.03 |
Heart | 0.20 ± 0.01 | 0.21 ± 0.02 | 0.22 ± 0.02 | 0.20 ± 0.01 | 0.20 ± 0.01 |
Kidneys | 0.45 ± 0.04 | 0.47 ± 0.04 | 0.48 ± 0.08 | 0.45 ± 0.05 | 0.45 ± 0.04 |
Liver | 2.10 ± 0.19 | 2.08 ± 0.21 | 2.11 ± 0.14 | 2.09 ± 0.12 | 2.01 ± 0.20 |
Spleen | 0.17 ± 0.02 | 0.17 ± 0.01 | 0.18 ± 0.02 | 0.17 ± 0.03 | 0.17 ± 0.02 |
Testes | 0.64 ± 0.05 | 0.69 ± 0.08 | 0.65 ± 0.08 | 0.65 ± 0.06 | 0.68 ± 0.08 |
Female rats | |||||
Adrenal glands | 0.019 ± 0.003 | 0.019 ± 0.002 | 0.019 ± 0.003 | 0.020 ± 0.003 | 0.020 ± 0.003 |
Brain | 0.59 ± 0.06 | 0.65 ± 0.07a | 0.64 ± 0.07a | 0.64 ± 0.06a | 0.65 ± 0.04a |
Heart | 0.25 ± 0.02 | 0.26 ± 0.02 | 0.27 ± 0.03 | 0.26 ± 0.02 | 0.26 ± 0.02 |
Kidneys | 0.48 ± 0.05 | 0.51 ± 0.04 | 0.50 ± 0.05 | 0.52 ± 0.05a | 0.52 ± 0.04a |
Liver | 2.01 ± 0.19 | 2.05 ± 0.18 | 2.02 ± 0.15 | 2.06 ± 0.11 | 2.06 ± 0.15 |
Ovaries | 0.018 ± 0.006 | 0.019 ± 0.003 | 0.021 ± 0.004 | 0.021 ± 0.007 | 0.021 ± 0.006 |
Spleen | 0.20 ± 0.03 | 0.21 ± 0.02 | 0.19 ± 0.03 | 0.20 ± 0.03 | 0.22 ± 0.05 |
Uterus | 0.26 ± 0.06 | 0.28 ± 0.07 | 0.24 ± 0.06 | 0.25 ± 0.05 | 0.25 ± 0.05 |
*Statistically significant difference to the control value based on the 95% confidence interval