Table 2.
Haematology parameters (mean ± SD) in the serum of male and female Wistar Han RCC rats in the 90-day feeding trial with GM maize NK603 at an inclusion rate of 11 and 33% in the diet
| Parameter | 33% Control | 11% NK603 | 33% NK603 | 11% NK603 + Roundup | 33% NK603 + Roundup |
|---|---|---|---|---|---|
| Male rats | |||||
| WBC (109/L) | 9.10 ± 1.92 | 8.85 ± 1.58 | 9.42 ± 1.63 | 9.75 ± 1.22 | 9.57 ± 1.04 |
| RBC (1012/L) | 7.79 ± 0.30 | 7.77 ± 0.44 | 7.77 ± 0.27 | 7.67 ± 0.35 | 7.83 ± 0.20 |
| HGB (g/dL) | 14.6 ± 0.41 | 14.7 ± 0.29 | 14.7 ± 0.44 | 14.4 ± 0.55 | 14.8 ± 0.18 |
| HCT (%) | 42.4 ± 1.21 | 42.8 ± 1.96 | 43.0 ± 1.40 | 42.4 ± 1.60 | 43.2 ± 0.84 |
| MCV (fL) | 54.4 ± 1.07 | 55.2 ± 1.44 | 55.4 ± 1.16 | 55.4 ± 1.38 | 55.1 ± 0.63 |
| MCH (pg) | 18.8 ± 0.46 | 18.7 ± 0.52 | 19.0 ± 0.69 | 18.8 ± 0.78 | 19.0 ± 0.45 |
| MCHC (g/dL) | 34.6 ± 0.28 | 33.9 ± 0.94* | 34.2 ± 0.78 | 33.9 ± 0.59* | 34.4 ± 0.76 |
| PLT (109/L) | 842 ± 75 | 792 ± 120 | 862 ± 125 | 851 ± 83 | 847 ± 115 |
| LYMR (%) | 73.0 ± 3.74 | 72.5 ± 4.97 | 70.9 ± 5.89 | 72.0 ± 3.41 | 73.4 ± 5.06 |
| LYMA (103/µL) | 6.64 ± 1.55 | 6.42 ± 1.24 | 6.68 ± 1.34 | 7.00 ± 0.70 | 7.04 ± 1.09 |
| Lymphocytes (%) | 71.4 ± 6.45 | 68.1 ± 6.48 | 65.8 ± 5.86* | 69.8 ± 6.53 | 70.6 ± 6.28 |
| Neutrophils (%) | 25.7 ± 6.58 | 28.8 ± 7.01 | 30.5 ± 5.17* | 26.8 ± 6.83 | 26.4 ± 6.60 |
| Monocytes (%) | 1.50 ± 0.46 | 1.66 ± 0.44 | 1.78 ± 0.92 | 1.53 ± 0.41 | 1.31 ± 0.42 |
| Eosinophils (%) | 1.44 ± 0.58 | 1.41 ± 0.72 | 1.84 ± 1.32 | 1.91 ± 0.90 | 1.72 ± 0.78 |
| Female rats | |||||
| WBC (109/L) | 5.52 ± 1.48 | 5.37 ± 0.97 | 6.06 ± 1.16 | 4.86 ± 0.70 | 5.43 ± 1.26 |
| RBC (1012/L) | 6.73 ± 0.22 | 6.72 ± 0.55 | 6.87 ± 0.17 | 6.81 ± 0.50 | 6.66 ± 0.30 |
| HGB (g/dL) | 13.7 ± 0.45 | 13.6 ± 1.03 | 14.1 ± 0.18 | 13.8 ± 0.81 | 13.6 ± 0.65 |
| HCT (%) | 39.4 ± 1.09 | 39.1 ± 3.29 | 40.5 ± 0.95 | 39.9 ± 2.57 | 39.6 ± 1.81 |
| MCV (fL) | 58.7 ± 1.40 | 58.2 ± 1.79 | 59.1 ± 1.03 | 58.7 ± 1.63 | 59.6 ± 1.32 |
| MCH (pg) | 20.4 ± 0.69 | 20.2 ± 0.54 | 20.6 ± 0.44 | 20.4 ± 0.84 | 20.4 ± 0.62 |
| MCHC (g/dL) | 34.8 ± 0.83 | 34.7 ± 0.75 | 34.8 ± 0.64 | 34.7 ± 0.93 | 34.3 ± 0.47 |
| PLT (109/L) | 902 ± 113 | 825 ± 144 | 901 ± 91 | 813 ± 100 | 904 ± 94 |
| LYMR (%) | 75.2 ± 5.81 | 75.1 ± 3.52 | 77.5 ± 3.52 | 76.6 ± 4.92 | 77.1 ± 4.96 |
| LYMA (103/µL) | 4.22 ± 1.37 | 4.04 ± 0.69 | 4.69 ± 0.91 | 3.71 ± 0.69 | 4.15 ± 0.97 |
| Lymphocytes (%) | 69.2 ± 5.98 | 69.5 ± 6.24 | 70.4 ± 3.79 | 71.9 ± 5.15 | 71.1 ± 4.08 |
| Neutrophils (%) | 28.1 ± 4.73 | 28.5 ± 5.76 | 26.8 ± 4.46 | 26.1 ± 5.02 | 26.1 ± 4.18 |
| Monocytes (%) | 1.53 ± 0.76 | 1.12 ± 0.65 | 1.44 ± 0.83 | 1.12 ± 0.38 | 1.25 ± 0.57 |
| Eosinophils (%) | 1.16 ± 1.20 | 0.91 ± 0.71 | 1.31 ± 0.94 | 0.88 ± 1.03 | 1.56 ± 0.98 |
Eight cages/group, two rats/cage
*Statistically significant difference to the control value based on the 95% confidence interval