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. 2019 Feb 12;93(4):1095–1139. doi: 10.1007/s00204-019-02400-1

Table 9.

Clinical biochemistry parameters (mean ± SD) in the serum of male and female Wistar Han RCC rats in the 90-day feeding trial with GM maize NK603 at an inclusion rate of up to 50% in the diet

Parameter 33% Control 50% Control 11% NK603 33% NK603 50% NK603 11% NK603 + Roundup 33% NK603 + Roundup 50% NK603 + Roundup
Male rats
 ALP (µkat/L) 1.39 ± 0.29 1.28 ± 0.19 1.47 ± 0.32 1.29 ± 0.18 1.19 ± 0.15 1.20 ± 0.21 1.35 ± 0.22 1.33 ± 0.30
 ALT (µkat/L) 0.53 ± 0.07 0.54 ± 0.10 0.66 ± 0.17 0.52 ± 0.08 0.53 ± 0.08 0.64 ± 0.34 0.55 ± 0.07 0.57 ± 0.10
 AST (µkat/L) 2.42 ± 0.45 2.37 ± 0.37 2.92 ± 1.01 2.28 ± 0.30 2.46 ± 0.54 2.67 ± 0.68 2.39 ± 0.24 2.57 ± 0.71
 ALB (g/L) 38.4 ± 1.58 37.5 ± 0.64 39.3 ± 2.95a 38.2 ± 1.48 38.3 ± 0.82 39.0 ± 3.75 38.3 ± 1.36 38.4 ± 0.67
 TP (g/L) 66.2 ± 2.26 64.2 ± 0.76b 65.5 ± 2.10 65.4 ± 1.26 65.4 ± 0.67 64.6 ± 1.71 65.7 ± 1.69 65.6 ± 1.01
 GLU (mmol/L) 5.74 ± 0.61 5.58 ± 0.90 5.45 ± 0.84 5.40 ± 0.33 5.22 ± 0.76 5.70 ± 0.48 5.29 ± 0.33 5.03 ± 0.69
 CHOL (mmol/L) 2.15 ± 0.24 2.13 ± 0.26 2.11 ± 0.17 2.08 ± 0.17 2.23 ± 0.14 2.25 ± 0.09 2.11 ± 0.22 2.26 ± 0.26
 TAG (mmol/L) 1.07 ± 0.24 1.13 ± 0.30 1.12 ± 0.17 1.27 ± 0.24 1.18 ± 0.17 1.18 ± 0.23 1.12 ± 0.22 1.20 ± 0.24
 CREA (mmol/L) 36.2 ± 5.35 33.4 ± 5.31 32.3 ± 3.34 34.4 ± 4.11 34.9 ± 6.61 32.2 ± 7.05 33.3 ± 7.31 33.3 ± 5.95
 UREA (mmol/L) 5.46 ± 0.97 4.96 ± 0.56 4.91 ± 0.90 4.84 ± 0.87b 4.69 ± 0.39 5.50 ± 0.79a 5.31 ± 0.57 4.86 ± 0.70
 Ca (mmol/L) 2.39 ± 0.04 2.39 ± 0.04 2.37 ± 0.04 2.40 ± 0.05 2.40 ± 0.04 2.39 ± 0.04 2.39 ± 0.04 2.39 ± 0.03
 Cl (mmol/L) 99 ± 1.95 100 ± 1.03 100 ± 1.90 100 ± 2.42 101 ± 2.19 100 ± 2.63 100 ± 2.31 99 ± 1.36
 K (mmol/L) 4.56 ± 0.27 4.44 ± 0.21 4.89 ± 0.88a 4.51 ± 0.37 4.66 ± 0.37 4.50 ± 0.24 4.43 ± 0.19 4.56 ± 0.21
 Na (mmol/L) 144 ± 2.43 144 ± 1.75 143 ± 1.67 143 ± 1.77 145 ± 1.70 143 ± 2.10 145 ± 2.40 143 ± 2.41
 P (mmol/L) 2.19 ± 0.41 2.00 ± 0.14 2.11 ± 0.26 2.22 ± 0.19 1.99 ± 0.23 2.02 ± 0.42 2.22 ± 0.21 2.04 ± 0.19
Female rats
ALP (µkat/L) 0.64 ± 0.08 0.66 ± 0.14 0.59 ± 0.11 0.72 ± 0.14 0.64 ± 0.13 0.63 ± 0.13 0.62 ± 0.16 0.68 ± 0.10
ALT (µkat/L) 0.50 ± 0.08 0.48 ± 0.06 0.48 ± 0.06 0.47 ± 0.06 0.49 ± 0.07 0.48 ± 0.04 0.43 ± 0.10b 0.50 ± 0.08d
AST (µkat/L) 2.40 ± 0.30 2.22 ± 0.45 2.36 ± 0.57 2.21 ± 0.38 2.44 ± 0.60 2.29 ± 0.58 2.48 ± 0.67 2.29 ± 0.43
ALB (g/L) 44.4 ± 2.39 44.0 ± 2.00 42.7 ± 1.48 46.1 ± 3.07 44.7 ± 1.87 43.1 ± 1.59 44.7 ± 2.08 42.7 ± 2.54d
TP (g/L) 70.4 ± 3.06 69.2 ± 2.44 68.6 ± 1.98 72.1 ± 4.36 70.4 ± 2.27 68.4 ± 2.05 70.1 ± 3.21 68.6 ± 4.49
GLU (mmol/L) 4.87 ± 0.56 5.24 ± 0.90 4.95 ± 0.76 5.16 ± 0.50 5.01 ± 0.77 5.25 ± 1.03 5.05 ± 0.72 5.36 ± 0.88
CHOL (mmol/L) 1.83 ± 0.34 1.63 ± 0.23 1.57 ± 0.41 1.95 ± 0.35 1.65 ± 0.44c 1.54 ± 0.30 1.68 ± 0.29 1.34 ± 0.19a,d
TAG (mmol/L) 0.56 ± 0.12 0.52 ± 0.09 0.51 ± 0.13 0.56 ± 0.07 0.48 ± 0.06 0.48 ± 0.09 0.54 ± 0.15 0.43 ± 0.11a,d
CREA (mmol/L) 35.4 ± 3.91 36.5 ± 3.11 38.5 ± 6.08 35.3 ± 3.06 37.7 ± 4.34 37.6 ± 3.50 37.6 ± 3.58 34.0 ± 4.00d
UREA (mmol/L) 5.48 ± 0.33 5.93 ± 0.59 6.47 ± 0.80 5.96 ± 0.76 5.87 ± 0.64 6.36 ± 0.54 5.90 ± 0.55 5.85 ± 0.81
Ca (mmol/L) 2.46 ± 0.05 2.46 ± 0.03 2.43 ± 0.05 2.49 ± 0.06 2.46 ± 0.04 2.43 ± 0.04 2.41 ± 0.03b 2.42 ± 0.03a
Cl (mmol/L) 101 ± 1.41 103 ± 1.87b 102 ± 1.83 102 ± 2.20 102 ± 0.99 102 ± 1.45 101 ± 1.33 102 ± 1.35
K (mmol/L) 4.09 ± 0.20 4.19 ± 0.23 4.31 ± 0.46 4.24 ± 0.48 4.09 ± 0.34 4.17 ± 0.46 4.32 ± 0.67 4.15 ± 0.46
Na (mmol/L) 143 ± 2.11 144 ± 1.28 143 ± 1.69 144 ± 1.49 144 ± 1.39 143 ± 0.90 144 ± 1.62 143 ± 1.51
P (mmol/L) 1.62 ± 0.36 1.65 ± 0.40 1.63 ± 0.32 1.84 ± 0.30 1.64 ± 0.17 1.66 ± 0.30 1.87 ± 0.38 1.71 ± 0.36

aStatistically significant difference to the 50% control value based on the 95% confidence interval

bStatistically significant difference to the 33% control value based on the 95% confidence interval

cStatistically significant difference to the 33% NK603 value based on the 95% confidence interval

dStatistically significant difference to the 33% NK603 + Roundup value based on the 95% confidence interval