Figure 1.

Quantitative MRN markers. Mean and individual values of sciatic nerve magnetization transfer ration (MTR; A) and cross sectional area (CSA; B) are plotted for controls, asymptomatic mutTTR‐carriers, and symptomatic ATTRv‐PNP patients. Sciatic nerve MTR was highest in healthy controls, decreased significantly in asymptomatic mutTTR‐carriers, and even more in symptomatic ATTRv‐PNP patients. Inversely, sciatic nerve CSA was significantly higher in asymptomatic mutTTR‐carriers, and in symptomatic ATTRv‐PNP patients. Note that individual MTR values in healthy controls showed a wider distribution than in asymptomatic mutTTR‐carriers, and especially in symptomatic ATTRv‐PNP patients. Contrariwise, individual CSA values presented with a wider distribution in asymptomatic mutTTR‐carriers and even more in symptomatic ATTRv‐PNP patients compared to healthy controls. Error bars represent SEM. Significant differences are indicated by P‐values.