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. 2020 Apr 15;7(5):707–721. doi: 10.1002/acn3.51038

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© 2020 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals LLC on behalf of American Neurological Association

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Volume and flortaucipir findings across AD phenotypes within the 70+ genarian. Significance scaling hypothesis error plots are shown in the left column. The ellipse represents within‐group variation (how much the individuals vary from the group mean), with the line representing between‐group (i.e., Ty‐AD (T) vs. Aty‐AD (A)) variation. Significance scaling was applied so that if the line extends outside the ellipse the multivariate test is significant at P < 0.05 (P values shown in each plot). The black dots represent group means. The plots in the middle (atypical AD vs. typical AD) and right (PCA (P) vs. LPA (L)) columns show estimated group means with 95% confidence interval error bars (red vertical for flortaucipir and blue horizontal for volume). If error bars do not cross then group means can be considered significantly different. The greater the separation of the crosses the more significant the difference which applies to vertical and horizontal separations for the variables labeled on each axis.