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PDH-deficient mutants are viable in vitro and fully virulent in mice. A, plaque assays comparing overall growth of the indicated strains. B, relative size of plaques in A (means ± S.E. of more than 120 plaques from three assays; ***, p < 0.001; one-way ANOVA with Bonferroni's post-test). a.u., arbitrary units. C, survival rates of mice infected with the parental and mutant strains.
