Fig. 8.

Significantly restored 29 kinases (opposite to D/N; at least log₂ fold change ± 0.3 in DG/D) to normal status showing the homology of the kinase domains and protein posttranslational modifications. The rims indicate, the ratio of D/N (inner rim) or DG/D (outer rim) by color bar (bottom left) on recovered kinase in the respective PTM group such as nonmodification (green rim), phosphorylation (orange rim), or formerly sialylated N-linked glycosylation (SA, purple rim). D: db/db mouse islets, N: wild type mouse islets, DG: db/db mouse islets exposed to euglycemia. Among 29 restored kinases in phosphorylation or SA group, light yellow marked gene symbol indicate the newly identified phosphosite or SA site in PubMed. Pie chart for the restored kinase classification according to cellular component by Uniprot search (bottom right).