Fig. 9.

Dynamics of functional activity for canonical signaling pathways in the Ingenuity Pathway Analysis (IPA). A, For the protein group, combined violin plot with box plot shows significant inhibition or activation of z-scores in 3 overrepresented pathways based on p value (as an index of confidence in the overlap) as recovered canonical pathways to normal status in obese diabetic db/db mouse islets exposed to normal glucose concentrations. B, The phosphopeptides group. C, The SA peptides group. Significantly restored proteins or PTMs shown in box plot as outlier based on statistical significance of IQR test.