Table 1.
Antileishmanial and cytotoxicity activities.
| Cytotoxicity on RAW cells | L. major promastigotes | L. donovani promastigotes | |||
|---|---|---|---|---|---|
| CC50 (μM) | IC50 (μM) | SI | IC50 (μM) | SI | |
| Hardwickiic acid | 247.83 ± 6.32 | 62.82 ± 2.53 | 3.94 | 31.57 ± 0.14 | 7.85 |
| Curcumin | 29.99 ± 2.82 | ND | ND | ND | ND |
| Amphotericin B | ND | 3.67 ± 0.14 | ND | 3.35 ± 0.14 | ND |
Concentration of compounds which inhibited parasite proliferation by 50% (IC50); concentration of compounds which inhibited normal mammalian cells proliferation by 50% (CC50); and not determined (ND).