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. 2020 May 25;11:768. doi: 10.3389/fphar.2020.00768

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Copyright © 2020 Liu, Pan, Cheng, Deng, He, Zhang, Ning and Li

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Tubeimoside I (TBMS1) inhibits Yoda1-induced dilation in aorta. (A) Aorta pre-constricted with PE and exposed to 5 μM Yoda1. (B) As shown in (A) but after aorta pretreatment for 30 min with 10 μM TBMS1. (C) Summary of the results in (A, B) expressed as the percentage relaxation evoked by Yoda1. Each data point represents a value from an independent experiment. Error bars represent SEM (n = 6). *P < 0.05. (D, E) Analysis of the PE and Ach response in the presence of TBMS1 revealed no significant inhibition. Error bars represent SEM (n = 6). *P < 0.05.