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Schematic illustration of anti-inflammatory responses of circumdatin D. Circumdatin D negatively regulated TLR4-mediated NF-κB, MAPKs and JAK/STAT inflammatory signaling pathway and reduced the production of pro-inflammatory factors from LPS stimulated microglia. ERK, extracellular signal‐regulated kinase; JNK, c‐Jun N‐terminal kinase; NF‐kB, nuclear factor kappa‐light‐chain‐enhancer of activated B cells; TNF‐α, tumor necrosis factor‐α; IL‐1β, interleukin‐1β.
