TABLE 3.

Candidate responsive promoters to diacetyl.

Promoter	Gene	FOLD up-regulation	adj. P-value	Product
Pdar/ PplpA	dar	2.2	6E-03	Acetoin(diacetyl)reductase
	plpD	2.3	2E-02	D-Methionine-binding lipoprotein
Prib	ribA	3.3	2E-02	Riboflavin biosynthesis protein
	ribB	4.2	5E-03	Riboflavin synthase subunit alpha
	ribD	4.9	4E-03	Riboflavin biosynthesis protein
	ribH	6.6	4E-03	6,7-Dimethyl-8-ribityllumazine synthase
PcbiO1/ PcbiO2	cbiO	2.4	5E-03	Cobalt ABC transporter ATP-binding protein
	cbiQ	2.6	2E-02	Cobalt ABC transporter permease
P0295	llmg_0295	25.6	4E-04	Hypothetical protein
P2369	llmg_2368	16.3	2E-04	Hypothetical protein
	llmg_2369	9.2	6E-04	Hypothetical protein

Differentially expressed transcriptional units or single genes upregulated as a result of the presence of diacetyl in the medium. Genes with a differential expression ≥ 2.5 fold with a P ≤ 0.05, or previously reported in the literature to be related to diacetyl were selected.