TABLE 5.

Tige and Erava MICs in E. faecalis derivatives overexpressing candidate genes and their influence on PAP.

Transformed plasmid	Strain	MIC (mg/l)
		Parent isolates		Derivative isolates		PAP test results for derivative isolates
		Tige	Erava	Tige	Erava	Tige	Erava
pRS00630	EF16C2	0.125	0.125	0.125	0.125	Positive	Positive
	EF16C284	0.0625	0.125	0.0625	0.125	Positive	Positive
pRS02205	EF16C2	0.125	0.0625	0.125	0.0625	0	0
	EF16C105	0.0625	0.125	0.0625	0.125	0	0
pRS06145	EF16C283	0.0625	0.125	0.0625	0.125	Positive	0
pRS06880	EF16C284	0.0625	0.125	0.0625	0.125	Positive	0
pRS11485	EF16C2	0.125	0.125	0.125	0.125	0	0
	EF16C105	0.0625	0.125	0.0625	0.125	0	0
	EF16C39	0.125	0.125	0.125	0.125	0	0
pRS12140	EF16C105	0.0625	0.125	0.0625	0.125	Positive	0
	EF16C39	0.125	0.125	0.125	0.125	Positive	0

Erava, Eravacycline; MIC, minimum inhibitory concentration; PAP, population analysis profiling; Tige, tigecycline.