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. 2020 May 25;8:491. doi: 10.3389/fbioe.2020.00491

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Copyright © 2020 Di Santo, Digiacomo, Quagliarini, Capriotti, Laganà, Zenezini Chiozzi, Caputo, Cascone, Coppola, Pozzi and Caracciolo.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Personalization of protein corona depends on protein concentration. Cartoon describing our present understanding of the role of protein concentration on personalization of protein corona. When GO nanoflakes are incubated with human plasma (HP) a complex protein corona forms at the GO surface. When undiluted HP is used, the coronas of healthy donors and PDAC patients are not discernible. On the other side, after exposure of GO nanoflakes to highly diluted HP (dilution factor >200) characterization of the protein corona allows to distinguish between the two classes of donors.