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The workflow of experiments and bioinformatic analysis. Male Sprague-Dawley rats were treated with streptozotocin (STZ) or citrate buffer and after 8 weeks Schwann cells were isolated from sciatic nerves of rats for RNA-seq analysis. Gene ontology and KEGG pathway enrichment analyses were used to investigate the potential functions of the differentially expressed genes. lncRNA–mRNA co-expression network and ceRNA regulatory network were constructed by bioinformatics analysis methods.
