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. 2020 May 25;8:490. doi: 10.3389/fbioe.2020.00490

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Copyright © 2020 Wang, Xu, Chen, Kang, Guo, Duscher, Yang, Guo, Ren, Xiong, Yuan, Jiang, Machens, Chen and Chen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Evaluation of streptozotocin (STZ)-injected diabetic peripheral neuropathy (DPN) rat models. The differences between streptozotocin (STZ)-treated rats and control rats were calculated. The non-fasting blood glucose levels (B) were significantly higher in STZ-injected rats compared with control rats. The body weight (A), withdrawal threshold (E) and the motor and sensory nerve conduction velocities (F,G) in STZ-injected rats significantly decreased. The latency of hot plate test (C), tail flick test (D), and g-ratio of myelinated nerve fibers (H) significantly increased compared with controls (mean ± SEM, n = 10 per group, *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001). The detail of myelinated fibers was showed in (I). Scale bars: 1.0 μm.