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. 2020 May 25;8:490. doi: 10.3389/fbioe.2020.00490

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Copyright © 2020 Wang, Xu, Chen, Kang, Guo, Duscher, Yang, Guo, Ren, Xiong, Yuan, Jiang, Machens, Chen and Chen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Identification of mRNAs, lncRNAs, and miRNAs differentially expression in Schwann cells from streptozotocin (STZ)-treated rats and control rats. Hierarchical clustering analysis showed all differentially expressed mRNAs (A), lncRNAs (C), and miRNAs (E). Red color represented relatively high expression and green color represents relatively low expression. Volcano plots of normalized expression levels for differentially expressed mRNAs (B), lncRNAs (D) and miRNAs (F). The red points in the plots represented the upregulated RNAs with statistical significance and the blue points in the plots represented the downregulated RNAs with statistical significance (P-value < 0.05 and fold change > 1.2 or <0.83).