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. 2020 May 25;8:490. doi: 10.3389/fbioe.2020.00490

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Copyright © 2020 Wang, Xu, Chen, Kang, Guo, Duscher, Yang, Guo, Ren, Xiong, Yuan, Jiang, Machens, Chen and Chen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Competing endogenous RNA network in DPN model. The competing endogenous RNA network is based on miRNA-target relationship and co-expressed interactions between mRNA and lncRNA. The whole competing endogenous RNA network (A) in the DPN model. The sub competing endogenous RNA network (B) consists of miR-212-5p, 7 lncRNAs and 125 mRNAs. miRNA was indicated to V-shape, lncRNAs were indicated to round rectangle and mRNAs were indicated to ellipse. The red nodes represented upregulated RNAs and green nodes represented downregulated RNAs. The size of a node indicated the degree of node in the network.