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. 2020 May 25;11:513. doi: 10.3389/fphys.2020.00513

FIGURE 1.

FIGURE 1

Summary of Kv7.2 channel protein complex and its changes during M-current suppression, modified from ref (Kosenko et al., 2012). (A) Kv7.2 channel complex at the resting state. (B) Suppressed Kv7.2 channel through AKAP79/150-PKC pathway. Kv7.2 subunit is phosphorylated by AKAP79/150 anchored PKC when Gq-coupled receptors are activated. Phosphorylated Kv7.2 subunits release CaM, which reduces PIP2 binding to Kv7.2 subunit reducing functioning channels. (C) Suppressed Kv7.2 channel through intracellular calcium. Some Gq-coupled receptors suppress M-current via increase in intracellular calcium. Calcium-bound CaM changes configuration of Kv7.2 binding, which reduces PIP2 binding to Kv7.2 subunit.