Figure 3.

Majority of studies are conducted at early time points in ALS research and show that with early interventions there is a statistically significant improvement in survival. Forest plots showing the odds ratio and confidence intervals calculated from survival summary data study from each study, weighted by study size. Overall effect estimate is demonstrated (with 95% confidence intervals) as a black diamond at the bottom of the graph. Heterogeneity is displayed as an I² value. (A) Intervention delivered pre-symptom onset; (B) at symptom onset and (C) after symptom onset. (D) At end stage of disease. Results demonstrate an overall statistically significant effect favoring the targeting of proteostasis early in ALS (A).