Figure 5.

Arimoclomol demonstrates potential in modifying all secondary outcome measures tested. Forest plots showing the odds ratio (for survival) and SMD (for histological, behavioral and biochemical outcomes) and confidence intervals calculated from each study, weighted by study size. Overall effect estimate is demonstrated (with 95% confidence intervals) as a black diamond at the bottom of the graph. Heterogeneity is displayed as an I² value. (A) Studies assessing the effect of arimoclomol on survival (n = 4). (B) Studies assessing the effect of arimoclomol on histological outcomes (n = 16). (C) Studies assessing the effect of arimoclomol on behavioral outcomes (n = 10). (D) Studies assessing the effect of arimoclomol on biochemical outcomes (n = 9). Results demonstrate an overall statistically significant effect only on all secondary outcome measures when treating with arimoclomol (B–D).