Table 1.
List of interventions tested and putative pathways implicated.
| Intervention tested | Putative pathway |
|---|---|
| Clemastine | Protein clearance (autophagy) |
| Trichostatin A | Protein clearance (autophagy) |
| Methylene Blue | Chaperone activity |
| Lithium | Protein clearance (autophagy) |
| Dimebon | Chaperone activity |
| Brilliant blue G | Reduction in neuroinflammation (inhibits P2RY receptor) therefore reduction in ER stress |
| Rapamycin | Protein clearance (autophagy) |
| Latrepirdine | Physical modulation of misfolded proteins and blockade of calcium channels reducing excitotoxicity and subsequent ER stress |
| Recombinant Hsp70 | Chaperone activity |
| Riluzole | Chaperone activity (modulates HSF1 expression) |
| Resveratol | ER stress and autophagy |
| Follistatin | Protein clearance (autophagy) |
| Bosutinib | Protein clearance (autophagy) |
| Guanabenz | ER stress |
| Arimoclomol | Chaperone activity |
| Celastrol | Chaperone activity |
| Progesterone | Chaperone activity |
| Allopurinol | Autophagy and ER stress |
| Trehalose | Autophagy and ER stress |
| Zinc | Chaperone activity |
| Withaferin A | Ubiquitin proteasome system |
| 17-AAG (geldanamycin) | Autophagy and Chaperone activity |
| Cystatin C | Physical modulation of and binding to misfolded proteins and autophagy |
| Copper | Chaperone activity |
| Melittin (bee venom) | Autophagy and ER stress |
A table listing the therapeutic interventions analyzed as part of this systematic review including the putative pathway implicated in the mechanism of action. It is important to note however that drugs can modulate multiple potential targets, and that the dogma of ‘single drug, single target' is overly simplistic. This table is provided to give an overview of the interventions tested with information of a putative target with respect to its role in proteostasis, noting that many of these interventions will have other target effects not listed here.