TABLE 1.

Differentially expressed mitochondrial proteins in fibroblasts after treatment with 10 or 50 μM 3O-C₁₂-HSL for 4 h compared to the diluent control.

Identified proteins	UniProt accession	MW kDa	P-value emPAI ANOVA	Quantitative profile			Functional groups #
				Control	10 μM	50 μM
DnaJ homolog subfamily A member 1	DNJA1_MOUSE	45	0.012	High	High	Low	X		X		X
Cluster of ADP/ATP translocase 2	ADT2_MOUSE	33	0.011	High	Low	High	X
Prohibitin	PHB_MOUSE	30	0.0043	Low	High	Low		X
Metaxin-2	MTX2_MOUSE	30	0.024	Low	High	Low	X	X
39S ribosomal protein L38, mitochondrial	RM38_MOUSE	45	0.05	Low	High	Low				X
Thioredoxin-dependent peroxide reductase, mitochondrial	PRDX3_MOUSE	28	0.042	High	Low	Low		X	X

# Functional groups of human proteins: X – carrier and transport; X – structural organization; X – cell defense and response to stress and pathogens; X – ribosomal function; X – chaperone activity. STRING and SCAFFOLD analyses were used to group proteins into functional classes. Data are from six independent experiments.