TABLE 2.

Differentially expressed mitochondrial proteins in Caco-2 epithelial monolayers after treatment with 10 or 50 μM 3O-C₁₂-HSL for 4 h compared to the diluent control.

Identified proteins	UniProt accession	MW kDa	P-value emPAI ANOVA	Quantitative profile			Functional groups #
				Control	10 μM	50 μM
Peroxiredoxin-5, mitochondrial	PRDX5_HUMAN	22	0.0024	Low	High	High		X
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8	NDUA8_HUMAN	20	0.011	Low	High	High	X
Periplakin	K7EKI8_HUMAN	204	0.021	Low	High	High			X
Prostaglandin E synthase 2	PTGES2_HUMAN	42	0.039	Low	High	High				X
Isoform 2 of 39S ribosomal protein L47, mitochondrial	RM47_HUMAN	27	0.041	High	High	Low						X
Peroxisomal bifunctional enzyme	ECHP_HUMAN	79	0.02	High	Low	High				X
Cytochrome c1, heme protein, mitochondrial	CY1_HUMAN	35	0.04	High	Low	High	X			X
Cluster of NAD transhydrogenase	NNTM_HUMAN	114	0.024	Low	Low	High	X
GrpE protein homolog 1, mitochondrial	GRPE1_HUMAN	24	0.034	Low	Low	High		X			X
Cluster of isoform 2 of MICOS complex subunit MIC60	MIC60_HUMAN	83	0.035	Low	Low	High			X
Stress-70 protein, mitochondrial	GRP75_HUMAN	74	0.041	Low	Low	High		X			X
Succinate–CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial	SUCA_HUMAN	36	0.0078	High	Low	Low	X
Succinate dehydrogenase assembly factor 2, mitochondrial	F5GYJ5_HUMAN	18	0.0091	High	Low	Low	X
Cytochrome c oxidase subunit 5B, mitochondrial	COX5B_HUMAN	14	0.012	High	Low	Low	X

# Functional groups of human proteins: X – respiratory chain complexes; X – cell defense and response to stress and pathogens; X – structural organization; X – lipid metabolism and heme binding; X – chaperone activity; X – ribosomal function. STRING and SCAFFOLD analyses were used to group proteins into functional classes. Data are from six independent experiments.