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. 2020 May 21;11:709. doi: 10.3389/fphar.2020.00709

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Copyright © 2020 Panes, Godoy, Silva-Grecchi, Celis, Ramirez-Molina, Gavilan, Muñoz-Montecino, Castro, Moraga-Cid, Yévenes, Guzmán, Salisbury, Trushina and Fuentealba

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Immunohistochemistry of PGC-1α after acute and sub-chronic treatments of AβOs in mice hippocampal slices. (A) Maximum intensity projections of confocal images showing neurons from the granular layer of the dentate gyrus in mice hippocampus stained for: PGC-1α (yellow), MAP2 (violet, for neurons), and DAPI (cyan, for nucleus). (B) Maximum intensity projections of stacked confocal images showed in (A). (C) Normalized quantification of the fluorescence intensity for PGC-1α normalized with respect to MAP2 immunofluorescence in control condition and after AβOs (0.5 μM) exposure for 1 or 5 h. Scale bars: 5 μm. Data analyzed using one way ANOVA with Kruskall-Wallis test and Dunn's Multiple Comparison test. (*p < 0.05 vs control nroi: 462/nslices: 75, AβOs 1H nroi: 664/nslices: 37, AβOs 5H nroi: 977/nslices: 30/per each independent experiment, n=3).