Table 4.
IC50 values obtained in the N7‐methylation activity assay (Ecm1, RNMT–RAM, and VCE) for eight selected potential inhibitors and sinefungin as a control.[a]
|
Compound |
IC50 [μm] |
||
|---|---|---|---|
|
|
RNMT–RAM |
Ecm1 |
VCE |
|
aurintricarboxylic acid |
0.47±0.01 |
0.031±0.005 |
n.d. |
|
NF 023 |
1.80±0.33 |
0.015±0.005 |
n.d. |
|
reactive blue 2 |
3.30±0.73 |
0.043±0.007 |
n.d. |
|
suramin |
0.70±0.08 |
0.046±0.006 |
0.083±0.015 |
|
galloflavin |
n.d. |
0.12±0.02 |
n.d. |
|
quercetin |
n.d. |
0.12±0.02 |
n.d. |
|
myricetin |
n.d. |
0.14±0.01 |
n.d. |
|
8‐Me‐Gp3A |
39.3±7.6 |
5.21±0.68 |
31.0±6.8 |
|
sinefungin |
0.53±0.07 |
0.014±0.002 |
0.078±0.026 |
[a] Data are the means±SD of two or three independent experiments.