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. 2020 Aug 10;26(49):11266–11275. doi: 10.1002/chem.202001036

Table 4.

IC50 values obtained in the N7‐methylation activity assay (Ecm1, RNMT–RAM, and VCE) for eight selected potential inhibitors and sinefungin as a control.[a]

Compound

IC50m]

RNMT–RAM

Ecm1

VCE

aurintricarboxylic acid

0.47±0.01

0.031±0.005

n.d.

NF 023

1.80±0.33

0.015±0.005

n.d.

reactive blue 2

3.30±0.73

0.043±0.007

n.d.

suramin

0.70±0.08

0.046±0.006

0.083±0.015

galloflavin

n.d.

0.12±0.02

n.d.

quercetin

n.d.

0.12±0.02

n.d.

myricetin

n.d.

0.14±0.01

n.d.

8‐Me‐Gp3A

39.3±7.6

5.21±0.68

31.0±6.8

sinefungin

0.53±0.07

0.014±0.002

0.078±0.026

[a] Data are the means±SD of two or three independent experiments.