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Viperin‐derived ddhCTP and N4‐hydroxy‐cytidine.
ddhCTP is the natural antimetabolite of the innate antiviral defence metabolite produced by viperin. N4‐hydroxy‐cytidine analogues are often chosen as antiviral candidates, but if their chemical properties lead them to produce N4‐hydroxy‐cytidine, the molecule will be immediately phosphorylated and lead to a potent mutagen. Great care must therefore be taken when choosing the nucleoside analogues used as antivirals.
