Figure 2.

Translational pharmacokinetic/pharmacodynamic (PK/PD) simulation. Simulated scenarios of drug effect on in vitro replication rate based on reported hydroxychloroquine (HCQ) efficacy. ³ , ⁹ , ¹⁰ Viral kinetics were estimated from in vitro replication rate of severe acute respiratory syndrome‐coronavirus (SARS‐CoV)‐1 and unbound drug concentration in plasma and lungs were simulated with HCQ PK model. ¹² , ¹⁵ Solid continuous line represents the 50th percentile of the simulated data and shaded areas represent the 95% prediction intervals for median, 2.5th, and 97.5th percentiles obtained from 500 simulated datasets. Dotted horizontal lines represent the baseline level, whereas dashed vertical lines indicate the start of treatment.