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. 2020 May 12;108(2):253–263. doi: 10.1002/cpt.1856

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© 2020 The Authors. Clinical Pharmacology & Therapeutics published by Wiley Periodicals LLC on behalf of American Society for Clinical Pharmacology and Therapeutics.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

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Pharmacokinetic (PK) simulations for optimal dose. (a) Population PK plasma profiles following different twice daily regimens. (b) Population PK plasma profiles following different combinations of loading and maintenance dosing. (c) Proposed dosing schemes with interindividual variability. Hydroxychloroquine (HCQ) concentration is detectable in plasma for up to 21 days. Apparent in vitro half‐maximal effective concentration (EC_50s) were adjusted to account for plasma protein binding. QTc, corrected QT.