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Workflow for preclinical evaluation of 125I-KX1 in high-risk neuroblastoma. Nineteen human neuroblastoma cell lines were screened for cytotoxic sensitivity to 125I-KX1. IMR-05 and NLF were chosen as representative cell lines for downstream experiments. Radioligand binding assay, immunofluorescence microscopy, and further cytotoxicity screening were followed by in vitro and in vivo radiation dosimetry.
