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Dependency of 125I-KX1–induced DNA damage on PARP-1. (A) Immunofluorescence microscopy images with γH2AX show 125I-KX1–induced double-strand DNA breaks, which were substantially blocked with veliparib. (B) Quantification of fluorescence intensity revealed statistically significant γH2AX signal increase with 125I-KX1 relative to other conditions. ****P < 0.0001.
