TABLE 2.
Association of PTEN Immunohistochemistry Status with Clinical and Imaging Characteristics
| PTEN status: per-patient analysis* |
PTEN status: per-lesion analysis |
|||||
| Characteristic | Loss | Intact | P | Loss | Intact | P |
| n | 36 | 39 | 38 | 65 | ||
| Age (y) | 69 (55–84) | 71 (61–82) | 0.179 | NA | NA | |
| PSA (ng/mL) | 18.1 (5.4–100.0) | 12.3 (3.9–98.7) | 0.424 | NA | NA | |
| Prostate volume (cm3) | 40.6 (18.7–91.5) | 34.8 (12.6–110.9) | 0.597 | NA | NA | |
| Tumor diameter (cm) | 2.1 (1.1–4.5) | 2.1 (0.5–3.8) | 0.330 | 2.1 (0.6–4.5) | 1.2 (0.5–3.8) | 0.106 |
| GG | ||||||
| 1 | 0 (0.0) | 6 (15.4) | 0.202 (GG 1/2/3 vs. GG 4/5) | 2 (5.3) | 17 (26.2) | 0.062 (GG 1/2/3 vs. GG 4/5) |
| 2 | 15 (41.7) | 11 (28.2) | 15 (39.5) | 23 (35.4) | ||
| 3 | 10 (27.8) | 15 (38.5) | 10 (26.3) | 16 (24.6) | ||
| 4 | 7 (19.4) | 3 (7.7) | 7 (18.4) | 5 (7.7) | ||
| 5 | 4 (11.1) | 4 (10.2) | 4 (10.5) | 4 (6.1) | ||
| pT stage | NA | NA | ||||
| 2 | 11 (30.6) | 14 (35.9) | 0.624 (pT2 vs. pT3) | |||
| 3a | 17 (47.2) | 21 (53.8) | ||||
| 3b | 8 (22.2) | 4 (10.3) | ||||
| 4 | 0 (0.0) | 0 (0.0) | ||||
| pN stage | 0.775 (pN0 vs. pN1) | NA | NA | |||
| 0 | 33 (91.7) | 35 (89.7) | ||||
| 1 | 3 (8.3) | 4 (10.3) | ||||
| Visible on MRI | 34 (94.4) | 37 (94.9) | 0.436 | 35 (92.1) | 60 (92.3) | 0.571 |
| Visible on PET | 36 (100.0) | 38 (97.4) | 0.374 | 37 (97.4) | 57 (87.0) | 0.162 |
| PI-RADS score | ||||||
| 3 | 0 (0.0) | 3 (8.1) | 0.313 (PI-RADS 3/4 vs. 5) | 0 (0.0) | 11 (18.3) | 0.117 (PI-RADS 3/4 vs. 5) |
| 4 | 13 (38.2) | 7 (18.9) | 14 (40.0) | 23 (38.3) | ||
| 5 | 21 (61.8) | 27 (73.0) | 21 (60.0) | 26 (43.4) | ||
| ADCmean (μm2/s) | 628.9 (462.4–724.3) | 620.3 (402.1–867.78) | 0.145 | 621.7 (462.4–735.0) | 616.0 (402.1–904.0) | 0.273 |
| Maximum diameter (cm) | 1.6 (0.8–4.3) | 1.8 (0.4–3.8) | 0.483 | 1.5 (0.8–4.3) | 1.2 (0.5–3.8) | 0.258 |
| SUVmax | 22.5 (7.7–41.3) | 8.7 (3.5–28.2) | <0.001† | 22.0 (6.9–41.3) | 8.2 (3.5–28.2) | <0.001† |
*Derived from index lesion on per-patient analysis.
†
P < 0.05.
NA = not applicable; PI-RADS = Prostate Imaging Reporting and Data System; maximum diameter = maximum diameter of lesion on MRI.
Categoric data are expressed as numbers followed by percentages in parentheses; continuous data are expressed as median followed by range in parentheses.