TABLE 1.

Parameters in Selecting Optimal Image Metrics for Response to Therapy

SUV metric	RC	F score	Uncertain fraction	QRAS
ΔSUVmax	0.73	0.73	0.45	0.45
ΔSUV25	0.28	0.72	0.31	0.12
ΔSUV25 (single slice)	0.33	0.74	0.34	0.15
ΔSUVP4	0.59	0.77	0.48	0.37
ΔSUVP14	0.47	0.74	0.34	0.22
ΔSUVP33	0.45	0.69	0.41	0.27

F score is derived from performance evaluation of response to therapy. “Uncertain fraction” is fraction of data points within limits of agreement for a given image metric QRAS=RC · (uncertain fraction)/(F score). Lower QRAS value is favorable.