Table 3.

Simulated unbound HCQ heart C_max values with HCQ dosing of 400 mg b.i.d. for 1 day followed by 200 mg b.i.d. for 4 days or 200 mg t.i.d. for 10 days

HCQ dosing regimen	Unbound Cmax day 1 (ng/mL)	Unbound Cmax day 3 (ng/mL)	Unbound Cmax day 5 (ng/mL)	Unbound Cmax day 10 (ng/mL)
400 mg b.i.d. for 1 day followed by 200 mg b.i.d. for 4 days	20,600	24,100	32,050	21,800
200 mg t.i.d. for 10 days	14,450	28,400	40,750	68,500

C_max, maximum concentration; HCQ, hydroxychloroquine; PBPK, physiologically based pharmacokinetic; K _P, partitioning coefficient.