Fig. 2.

Induction of PBMC ISG expression by RG7834 alone and in combination therapy. Kinetics of ISG (ISG15, MX1, CXCL10, and USP18) gene expressions were measured by reverse‐transcription polymerase chain reaction prior to (0 hours) and 6, 12, and 24 hours postsubcutaneous injection of the first wIFN dose. Fold‐change values were calculated relative to baseline (0 hours). Data show mean + SEM. Abbreviations: CXCL10, chemokine (C‐X‐C motif) ligand 10; h, hour; MX1, MX dynamin‐like guanosine triphosphatase 1; USP18, ubiquitin specific peptidase 18.