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. 2020 May 25;8:353. doi: 10.3389/fcell.2020.00353

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Copyright © 2020 Wang, Chu, Li, Zhang, Guo, Wu, Qiu, Li, Wan, Sui, Zhang, Xiang and Chen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Overexpression of COLGALT2 and confirmation of COLGALT2 inhibition and overexpression in osteosarcoma cells. (A) qRT-PCR analysis shows significantly upregulated COLGALT2 mRNA expression in MG63 and U-2OS cells compared to MCR-5 cells. (B) qRT-PCR analysis showed significantly decreased COLGALT2 mRNA expression in MG63 cells treated with COLGALT2 shRNA. (C) Immunoblotting assays showed that COLGALT2 inhibition decreased the protein expression of COLGALT2, vimentin and MMP2/9 in MG63 cells. (D) Immunoblotting assays show that COLGALT2 overexpression increased the protein expression of COLGALT2, vimentin, and MMP2/9 in U2-OS cells. ***P < 0.001, **P < 0.01.