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. 2020 May 25;8:353. doi: 10.3389/fcell.2020.00353

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Copyright © 2020 Wang, Chu, Li, Zhang, Guo, Wu, Qiu, Li, Wan, Sui, Zhang, Xiang and Chen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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COLGALT2 mediates the promotion effects of ADSC exosomes on osteosarcoma metastasis and growth in models of nude mice. (A) To inspect osteosarcoma xenograft luminescence activity, an in vivo imaging system was applied. The results indicated tumor metastasis and growth. (B) Living Image Software was used to examine the tumor bioluminescence intensity every 8 days. Additionally, the quantitation of the normalized image counts is displayed. (C) The immunohistochemical analysis of COLGALT2 and Ki67 expression in orthotopic tumor xenografts is shown. Scale bar: 25 μm. **P < 0.01.