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EScalate results demonstrating binding of each ligand to human and mouse plasma proteins. Data are expressed as mean ± SEM of the percentage of peptide unbound to plasma proteins determined in duplicate.
| Compound | Unbound fraction (fu) |
|
|---|---|---|
| Human plasma | Mouse plasma | |
| [G40,K41.C16 diacid]exendin-4 | 2.3% ± 1.0% | 2.6% ± 0.1% |
| [F1,G40,K41.C16 diacid]exendin-4 | 2.1% ± 0.1% | 2.4% ± 0.3% |
| [D3,G40,K41.C16 diacid]exendin-4 | 2.2% ± 0.1% | 2.1% ± 0.3% |
