. 2020 May 5;36:100690. doi: 10.1016/j.nmni.2020.100690

Table 2.

Antimicrobial resistance profiles and deduced amino acid substitution patterns in the transpeptidase region of penicillin-binding protein 3 (PBP3) of Haemophilus influenzae strains

Reference Strains	Resistance profile	Cefinase/bla genes	MICs			ftsI groupa		Mutations in ftsI gene
Reference Strains	Resistance profile	Cefinase/bla genes	AMP	AMC	CTX		D350	S357	M377	S385	L389	P392	N422	G490	A502	V511	R517	N526	S532	F535	V547	I549	Y557	N569
Hi 3	—	—	0.25	0.25	0.012	NA
Hi 7	—	—	0.25	0.38	0.016
Hi 9	TET	—	0.38	0.25	0.012
Hi 12	TET	—	0.19	0.125	0.023
Hi 13	—	—	0.25	0.125	0.016							P
Hi 11	TET	—	0.125	0.125	0.016															I
Hi 8	SXT	—	0.25	0.25	0.012															I
Hi 6	—	—	0.75	0.25	0.047																I
Hi 5	TET	—	0.5	0.38	0.08				s												I
Hi 2	—	—	0.25	0.25	0.016																	F
Hi 14	AMX-TET	—	2	0.125	0.064	Group I											H
Hi 1	AMX	—	4	0.125	0.023											A	H
Hi 10	AMX-TET	—	4	0.38	0.023											A	H
Hi 17^a	AMX-AMC-SXT	+/bla_TEM-1	>256	2	0.064	Group IIb	N		I						V			K		I
Hi 18 ^a	AMX-AMC	+/bla_TEM-1	>256	4	0.047	Group Iib	N		I					E	V			K
Hi 4 ^a	AMX-AMC-TET-SXT	+/bla_TEM-1	>256	2	0.047	Group Iib	N		I					E	V			K			I
Hi 15^b	AMX-AMC	+/bla_TEM-1	>256	2	0.032	Group II	N		I				I∗		V			K
Hi 19	AMX-AMC-CTX	+/bla_TEM-1	>256	>256	1	Group–III–like+	N	N	I	T	F						H		T		I		H	S
Hi 16	AMX-AMC-CTX-TET	—	24	4	0.5	Group III+	N	N	I	T	F				T			K

AMC, ampicillin/clavulanic acid; AMP, ampicillin, CTX, cefotaxime.

^a Classification according to Ubukata et al. [30] (Group I, II and III), Dabernat et al. [3] (Subgroup II: IIa, IIb, IIc and IId), García-Cobos et al. [4] (Group–III–like), Skaare et al. [23] (Group III+ and Group–III–like+): –, negative; NA, non-assigned resistance group, ∗, new mutation.