TABLE 1.

The core autophagy machinery proteins in C. neoformans.

Name	S. cerevisae	C. neoformans	Function	Identity (%)	Similarity (%)
Atg1	YGL180W	CNAG_05005	Protein serine/threonine kinase, regulates magnitude of autophagy	46	61
Atg2	YNL242W	CNAG_06732	Peripheral membrane protein, mediates the retrieval of Atg9 from the PAS back to peripheral sites	28	45
Atg3	YNR007C	CNAG_06892	E2-like conjugating enzyme, functions in the conjugation of Atg8-PE	35	48
Atg4	YNL223W	CNAG_02662	Cysteine protease, cleaves the C-terminal arginine residue from Atg8 or PE from Atg8-PE conjugate	33	47
Atg5	YPL149W	CNAG_06519	Conjugation target of Atg12, part of the Atg12-Atg5-Atg16 complex	17	33
Atg6	YPL120W	CNAG_01773	Subunit of class III PI3K complex I and II, functions in autophagy and the VPS pathway	32	47
Atg7	YHR171W	CNAG_04538	E1-like activating enzyme, functions in the conjugation of Atg12 and Atg5 or Atg8 and PE	37	52
Atg8	YBL078C	CNAG_00816	Ubiquitin-like protein, conjugated to PE, controls the phagophore expansion	78	90
Atg9	YDL149W	CNAG_01445	Transmembrane protein, cycles between the PAS and other cytosolic punctate structures	39	60
Atg12	YBR217W	CNAG_07645	Ubiquitin-like protein, conjugated to Atg5, part of the Atg12-Atg5-Atg16 complex	37	60
Atg13	YPR185W	CNAG_00778	Regulatory subunit of Atg1 complex, stimulates Atg1 activity and controls the magnitude of autophagy	36	60
Atg14	YBR128C	CNAG_03608	Autophagy-specific subunit of PI3K complex I, targets the complex I to the PAS	27	60
Atg16	YMR159C	CNAG_02576	Component of the Atg12-Atg5-Atg16 complex, mediates the oligomerization of the complex	35	62
Atg18	YFR021W	CNAG_02269	Phosphoinositide binding protein, binds PI3P and PI4P, interacts with Atg2 to mediate the retrieval of Atg9 from the PAS back to peripheral sites	35	52