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. Author manuscript; available in PMC: 2020 Jun 1.
Published in final edited form as: AIDS. 2020 Mar 15;34(4):559–567. doi: 10.1097/QAD.0000000000002451

Table 3.

Comparison of baseline cytology smear results for ASPIRE dapivirine vaginal ring arm, placebo vaginal ring arm and VOICE oral placebo arm participants with a final visit high-grade squamous intraepithelial lesion result.

HSIL at final visit
 P-value
Baseline cytology smear results Dapivirine vaginal ring (n = 7) Placebo vaginal ring (n = 6) Oral placebo (n = 12) Dapivirine versus placebo vaginal ring Dapivirine vaginal ring versus oral placebo Placebo vaginal ring versus oral placebo
Negative for intraepithelial lesion 4 (57%) 4 (67%) 5 (42%) 0.89 0.67 0.41
ASC-US 1 (14%) 1 (17%) 1 (8%)
LSIL 2 (29%) 1 (17%) 6 (50%)

P-value for comparison of baseline cytology smear results for ASPIRE dapivirine vaginal ring arm, placebo vaginal ring arm and VOICE oral placebo arm participants with a final visit HSIL result is from Cochran–Mantel–Haenszel tests for general association. ASC-US, atypical squamous cells of undetermined significance; HSIL, high-grade squamous intraepithelial lesion; LSIL, low-grade squamous intraepithelial lesion.