Figure 2.

APV Dose-Dependent Block of NMDAR

(A) Schematic of experiment: NMDAR currents in response to stimulating RGC axons (red) in the optic tract were recorded in whole-cell mode from tectal cells held at +40 mV holding potential in the presence of 20 μM NBQX and 100 μM picrotoxin.

(B) Averages of 20 traces of NMDAR-mediated excitatory postsynaptic currents recorded in the presence of increasing concentrations of DL-APV added to the bath.

(C) Relative total charge transfer normalized to 0 μM APV. 0 μM: 100%, 2 μM: 73.4% ± 10.4%, 5 μM: 53.4% ± 11.5%, 20 μM: 17.0% ± 7.5%. N = 5.