Figure 2.

Transcription Factors Remodel DNA Accessibility and Epigenetic Marks to Establish Cell Identity and Response to Exogenous Signals

(A) LDTFs establish cell-type-specific DNA accessibility landscapes.

(B) Exposure of cells to environmental signals such as MAMPs and DAMPs induces remodeling of chromatin by SDTF and chromatin remodeling complexes. This remodeling generally occurs at intermediately accessible regions, with constitutively active promoters and heterochromatin not affected. The newly established active or inactive regions influence the cell's response to future environmental signals.