Figure 2. Forest plot of fully adjusted hazard ratios for the outcomes for all analyses, comparing rates during periods of ACEI and ARB prescription.

*Adjusted for age (<55, 55–64, 65–74, 75–84, and ≥85 years), sex, year (1997–2001, 2002–2006, 2007–2011, 2012–2016), kidney function (eGFR ≥60 mL/min/1.73m ² or unmeasured, eGFR 45–59 mL/min/1.73m ², eGFR 30–44 mL/min/1.73m ², eGFR <30 mL/min/1.73m ², or renal replacement therapy), diagnoses of hypertension, diabetes, myocardial infarction, heart failure, and proteinuria: all covariates were time-updated.