TABLE 7.
HRs of VTE by Echocardiographie Measure in Participants Without Baseline HF (ARIC, 2011 to 2015)
| Model 1 |
Model 2 |
||||
|---|---|---|---|---|---|
| Echocardiographic Measure | HR (95% CI) | p Value | HR (95% CI) | p Value | |
| LV diastolic diameter (0.49 cm) | 1.00 (reference) | 0.98 (0.78–1.25) | 0.89 | 0.96 (0.76–1.21) | 0.72 |
| LVEF (6.1%) | 1.00 (reference) | 0.83 (0.68–1.02) | 0.08 | 0.87 (0.71–1.05) | 0.15 |
| LVEF category (<59% M, <57% W) | 1.00 (reference) | 1.83 (0.95–3.53) | 0.07 | 1.66 (0.85–3.23) | 0.14 |
| LV mass index (18.7 g/m2) | 1.00 (reference) | 1.25 (1.03–1.51) | 0.03 | 1.21 (1.00–1.48) | 0.05 |
| LV relative wall thickness (0.07 cm) | 1.00 (reference) | 1.26 (1.10–1.45) | 0.001 | 1.25 (1.09–1.44) | 0.002 |
| Mean LV wall thickness (0.13 cm) | 1.00 (reference) | 1.35 (1.13–1.62) | 0.001 | 1.32 (1.10–1.59) | 0.003 |
| RV diastolic area (5.2 cm2) | 1.00 (reference) | 0.89 (0.68–1.15) | 0.37 | 0.87 (0.70–1.13) | 0.30 |
| RV systolic area (2.9 cm2) | 1.00 (reference) | 0.84 (0.64–1.11) | 0.22 | 0.81 (0.62–1.07) | 0.14 |
| RV fractional area change (0.08) | 1.00 (reference) | 1.06 (0.84–1.33) | 0.65 | 1.08 (0.86–1.36) | 0.52 |
| LAVI (8.4 ml/m2) | 1.00 (reference) | 1.17 (1.03–1.32) | 0.02 | 1.13 (0.97–1.32) | 0.12 |
| LAVI category (>31 ml/m2 M, >30 ml/m2 W) | 1.00 (reference) | 1.47 (0.92–2.35) | 0.11 | 1.30 (0.81–2.11) | 0.28 |
| LAD (0.51 cm) | 1.00 (reference) | 1.21 (0.96–1.52) | 0.11 | 1.12 (0.88–1.42) | 0.34 |
| LAD category (>4.0 cm M, >3.7 cm W) | 1.00 (reference) | 1.70 (1.06–2.74) | 0.03 | 1.50 (0.92–2.44) | 0.10 |
| E/A ratio (0.28) | 1.00 (reference) | 1.11 (0.91–1.35) | 0.29 | 1.05 (0.87–1.27) | 0.62 |
| E/E′ lateral ratio (3.8 cm/s) | 1.00 (reference) | 1.14 (0.94–1.38) | 0.18 | 1.13 (0.94–1.36) | 0.19 |
| Lateral e/e′ ratio category (>11.5 M, >13.3 in W) | 1.00 (reference) | 0.85 (0.49–1.50) | 0.58 | 0.85 (0.48–1.50) | 0.58 |
| Tricuspid regurgitation velocity (0.28 cm/s) | 1.00 (reference) | 1.04 (0.80–1.34) | 0.77 | 1.02 (0.79–1.32) | 0.89 |
| Peak RV-RA gradient (5.7 mm Hg) | 1.00 (reference) | 1.04 (0.81–1.35) | 0.74 | 1.02 (0.79–1.32) | 0.86 |
| Pulmonary vascular resistance (0.42 Wood units) | 1.00 (reference) | 1.11 (0.87–1.43) | 0.40 | 1.05 (0.82–1.35) | 0.71 |
| Pulmonary HTN, moderate or greater | 1.00 (reference) | 1.87 (0.26–13.6) | 0.53 | 1.40 (0.19–10.2) | 0.74 |
| Septal e′ (1.5 cm/s) | 1.00 (reference) | 0.90 (0.72–1.13) | 0.37 | 0.88 (0.70–1.10) | 0.27 |
| Septal E/e′ (1.9 cm/s) | 1.00 (reference) | 0.95 (0.76–1.18) | 0.62 | 1.01 (0.81–1.26) | 0.92 |
| Longitudinal strain (2.4%) (absolute value) | 1.00 (reference) | 0.85 (0.69–1.05) | 0.13 | 0.89 (0.72–1.10) | 0.27 |
| Circumferential strain (3.7%) (absolute value) | 1.00 (reference) | 0.78 (0.62–0.99) | 0.04 | 0.81 (0.64–1.02) | 0.08 |
Model 1 adjusted for age (continuous), race, sex, body mass index (continuous), education (more than high school vs. not), hypertension, and aspirin use; model 2 adjusted for model 1 plus chronic kidney disease and atrial fibrillation. HRs for all continuous measures per 1 SD unit increase.