Table 3.

Univariate and multivariate Cox proportional hazards analysis of the prognostic values of lasso-Cox risk index and other prognostic factors. HR, hazard ratio. CI, confidence interval.

	Univariate Cox regression		Multivariate Cox regression
Variable	HR (95% CI)	P value	HR (95% CI)	P value
Lasso-Cox	3.06 (2.10–4.45)	5.02e-9	2.26 (1.46–3.49)	2.31e-4
Clinical
Grade	2.38 (1.63–3.5)	8.45e-6	1.46 (0.95–2.23)	8.22e-2
Stage	3.68 (2.57–5.27)	1.12e-12	3.00 (2.00–4.49)	9.23e-8
Gene expression
CSNK2A1	0.90 (0.64–1.26)	5.34e-1	1.07 (0.74–1.56)	7.11e-1
SPP1	1.15 (0.82–1.61)	4.14e-1	1.10 (0.75–1.63)	6.20e-1
DEFB1	1.41 (1.00–1.98)	4.99e-2	1.36 (0.95–1.95)	9.71e-2
PECAM1	0.77 (0.55–1.09)	1.40e-1	1.04 (0.69–1.58)	8.45e-1
EDNRB	0.50 (0.35–0.71)	9.10e-5	0.96 (0.59–1.57)	8.77e-1
TSPAN7	0.54 (0.38–0.76)	5.12e-4	1.03 (0.64–1.67)	9.07e-1
Somatic mutation
VHL	0.99 (0.70–1.38)	9.33e-1	1.23 (0.86–1.75)	2.57e-1
PBRM1	0.85 (0.58–1.24)	3.94e-1	1.03 (0.69–1.54)	8.85e-1
BAP1	1.49 (0.78–2.85)	2.22e-1	1.49 (0.74–3.00)	2.60e-1
SETD2	1.29 (0.77–2.14)	3.29e-1	1.03 (0.62–1.74)	9.00e-1
TP53	2.26 (1.00–5.15)	5.13e-2	2.86 (1.19–6.86)	1.85e-2