Table 5.
Urinary excretion of bone-forming minerals of the participants by group.
| Variable | Group A |
Group B |
||||
|---|---|---|---|---|---|---|
| Cases n = 24 | Controls n = 24 | p | Cases n = 38 | Controls n = 38 | p | |
| 2 hour fasted urine | ||||||
| uCa:Cr mol/mol* | 0.67 (0.21, 2.15) | 0.62 (0.24, 1.64) | 0.6 | 0.61 (0.18, 2.08) | 0.71 (0.27, 1.83) | 0.6 |
| uPhos:Cr mol/mol* | 5.52 (3.50, 8.69) | 3.73 (2.31, 6.01) | 0.009 | 4.79 (2.28, 10.1) | 3.60 (1.92, 6.77) | 0.04 |
| uMg:Cr (mol/mol)* | 0.83 (0.46, 1.50) | 0.47 (0.20, 1.13) | 0.1 | 0.68 (0.36, 1.29) | 0.46 (0.19, 1.08) | 0.3 |
| TmCa/GFR mmol/L | 1.96 (0.46) | 2.13 (0.45) | 0.02 | 1.93 (0.45) | 1.87 (0.42) | 0.08 |
| TmP/GFR mmol/L | 1.20 (0.36) | 1.92 (0.39) | ≤0.0001 | 1.88 (0.48) | 1.96 (0.46) | 0.3 |
| uCr mmol/2 h* | 0.036 (0.017, 0.077) | 0.055 (0.025, 0.119) | 0.009 | 0.059 (0.018, 0.194) | 0.075 (0.302,0.187) | 0.4 |
| Ccr mL/min* | 21.3 (8.72, 52.2) | 23.0 (9.60, 55.1) | 0.6 | 25.2 (7.48, 84.9) | 29.9(11.8, 75.7) | 0.6 |
| 24hour urine output | ||||||
| uCa mmol/24 h | 0.15 (0.06, 0.36) | 0.31 (0.14, 0.66) | ≤0.0001 | 0.29 (0.13, 0.64) | 0.41 (0.18, 0.94) | 0.02 |
| uPhos mmol/24 h | 2.56 (1.29, 5.08) | 2.93 (1.41, 6.11) | 0.5 | 3.17 (1.83, 5.49) | 3.41 (1.88, 6.19) | 0.5 |
| uMg mmol/24 h | 0.58 (0.29, 1.15) | 0.81 (0.41, 1.59) | 0.08 | 0.78 (0.41, 1.49) | 0.86 (0.46, 1.61) | 0.3 |
| uCr mmol/24 h* | 0.51 (0.27, 0.96) | 0.87 (0.48, 1.58) | 0.001 | 0.75 (0.46, 1.22) | 0.96 (0.53, 1.75) | 0.008 |
| uCa:Cr (mol/mol)* | 0.29 (0.13, 0.69) | 0.35 (0.17, 0.75) | 0.2 | 0.39(0.19, 0.81) | 0.42 (0.20, 0.89) | 0.6 |
| uPhos:Cr (mol/mol)* | 5.00 (3.73, 6.72) | 3.36 (2.35, 4.81) | ≤0.0001 | 4.22 (3.13, 5.69) | 3.54 (2.52, 4.97) | 0.02 |
| uMg/Cr (mol/mol) | 1.13 (0.69, 1.84) | 0.93 (0.60, 1.83) | 0.1 | 1.04 (0.66, 1.64) | 0.89 (0.53, 1.50) | 0.1 |
| Ccr mL/min* | 24.0 (11.4, 50.4) | 30.5 (15.3, 60.8) | 0.2 | 26.6 (16.2, 43.6) | 32.3 (18.7, 55.6) | 0.05 |
| uVolume (mL/24 h) | 436 (252) | 496 (212) | 0.2 | 497 (264) | 595 (342) | 0.06 |
For normally distributed data, the results are mean (standard deviation); for positively skewed data (denoted by *) the results are geometric mean (geometric mean-1SD, geometric mean + 1SD). Group A: active rickets, Group B: rickets-like bone deformities, u: urinary, Ca: Calcium, Phos: Phosphate, Mg: Magnesium, Cr: Creatinine, TmCa/GFR and TmP/GFR: Tubular maximum calcium or phosphate reabsorption per unit of glomerular filtrate rate respectively, Ccr: Creatinine clearance. Paired t-tests were used to calculate p-values for differences between cases and controls in Groups A and B with variables transformed to natural logarithms.