Table 1.
Cortical architecture and geometry of Dp1Tyb and control male and female mice at 6 and 16 weeks.
Male control 6 weeks |
Male Dp1Tyb 6 weeks |
Female control 6 weeks |
Female Dp1Tyb 6 weeks |
Between subjects effects Interaction |
Between subjects effects Genotype |
Between subjects effects Sex |
|
---|---|---|---|---|---|---|---|
n = 10 | n = 10 | n = 12 | n = 10 | ||||
Cortical area (mm2) | 0.82 (0.03)a | 0.58 (0.02)b | 0.71 (0.03)c | 0.56 (0.02)b | p = 0.091 [ηp2 = 0.074] |
p < 0.001 [ηp2 = 0.566] |
p = 0.026 [ηp2 = 0.124] |
Cortical thickness (mm) | 0.19 (0.005)a | 0.15 (0.003)b | 0.17 (0.008)a,b | 0.15 (0.007)b | p = 0.270 [ηp2 = 0.032] |
p < 0.001 [ηp2 = 0.367] |
p = 0.139 [ηp2 = 0.057] |
Imax (mm4) | 0.27 (0.01)a | 0.16 (0.01)b | 0.22 (0.01)c | 0.15 (0.01)b | p = 0.075 [ηp2 = 0.081] |
p < 0.001 [ηp2 = 0.585] |
p = 0.019 [ηp2 = 0.137] |
Imin (mm4) | 0.15 (0.01)a | 0.08 (0.004)b | 0.12 (0.005)c | 0.08 (0.003)b | p = 0.004 [ηp2 = 0.202] |
p < 0.001 [ηp2 = 0.740] |
p = 0.001 [ηp2 = 0.253] |
TMD (g/cm3 HA) | 1.05 (0.01)a | 0.99 (0.01)b | 1.05 (0.02)a | 1.01 (0.02)a,b | p = 0.655 [ηp2 = 0.005] |
p = 0.001 [ηp2 = 0.253] |
p = 0.592 [ηp2 = 0.008] |
Male control 16 weeks |
Male Dp1Tyb 16 weeks |
Female control 16 weeks |
Female Dp1Tyb 16 weeks |
Between subjects effects Interaction |
Between subjects effects Genotype |
Between subjects effects Sex |
|
---|---|---|---|---|---|---|---|
n = 13 | n = 12 | n = 20 | n = 22 | ||||
Cortical area (mm2) | 1.09 (0.02)e | 0.92 (0.02)f | 0.89 (0.01)f | 0.82 (0.01)g | p = 0.005 [ηp2 = 0.130] |
p < 0.001 [ηp2 = 0.476] |
p < 0.001 [ηp2 = 0.585] |
Cortical thickness (mm) | 0.24 (0.003)e | 0.24 (0.004)e | 0.22 (0.002)f | 0.22 (0.002)f | p = 0.184 [ηp2 = 0.0.30] |
p = 0.136 [ηp2 = 0.038] |
p < 0.001 [ηp2 = 0.341] |
Imax (mm4) | 0.43 (0.02)e | 0.29 (0.02)f | 0.26 (0.01)f | 0.21 (0.01)g | p = 0.001 [ηp2 = 0.189] |
p < 0.001 [ηp2 = 0.543] |
p < 0.001 [ηp2 = 0.681] |
Imin (mm4) | 0.20 (0.01)e | 0.12 (0.005)f,g | 0.13 (0.004)f | 0.11 (0.004)g | p < 0.001 [ηp2 = 0.241] |
p < 0.001 [ηp2 = 0.609] |
p < 0.001 [ηp2 = 0.452] |
TMD (g/cm3 HA) | 1.14 (0.02) | 1.14 (0.03) | 1.15 (0.02) | 1.17 (0.02) | p = 0.733 [ηp2 = 0.002] |
p = 0.889 [ηp2 = 0.000] |
p = 0.573 [ηp2 = 0.006] |
Values are averages (SEM). Similarities and differences between individual groups as determined from Tukey's multiple comparisons post hoc tests; values with the same superscript letter are not significantly different. Letters a,b,c,d are used for comparisons of 6 week old animals; letters e,f,g,h are used for comparisons of 16 week old animals. Data without letters within a single row are not significantly different from each other. Subject effects are p values and partial eta squared (ηp2) in brackets.